It has come to our attention that in the original article [1] information regarding dates was omitted. The data in this study were obtained in Switzerland four years before the entering into force of the new Swiss Human Research Act in 2014, when the guidelines of the Swiss Academy of Medical Sciences ceased to apply. It is important for readers to know that at the time of the study there was no binding law in Switzerland, only the more open SAMS (...) guidelines that have a different legal status. We would expect to find less variation of opinions among research ethics committee members if the study were repeated after the federal law came into force. (shrink)

Este artigo analisa a apresentação do tema da pleonexia por Trasímaco, personagem da República de Platão. Ele explota a sua descrição do funcionamento do kratos (predomínio) tal como ele o observa em cidades reais e a conclusão normativa que ele parece tirar deste diagnóstico: ter mais (pleon ekhein) é o caminho para a prosperidade. Do ponto de vista da caracterização do seu personagem, notaremos também as atitudes competitivas que Trasímaco demonstra no diálogo com Sócrates, fazendo parecer que a persuasão seria (...) uma disputa em que persuadir equivale a ganhar, enquanto ser persuadido equivaleria a perder; mas aprender por cooperação mútua não parece uma opção. O artigo se desenvolve em três partes: I) o tratamento erístico que Trasímaco dá à persuasão, II) a apresentação do tema do motivo psico-político através do emprego da palavra kratos e derivadas, III) a tematização que Trasímaco, Glauco e Sócrates fazem da pleonexia. (shrink)

In Switzerland, research with identifiable human tissue samples, and/or its accompanying data, must be approved by a research ethics committee before it can be allowed to take place. However, as the demand for such tissue has rapidly increased in recent years, and biobanks have been created to meet these needs, committees have had to deal with a growing number of such demands. Detailed instructions for evaluating every kind of tissue request are scarce. Committees charged with evaluating research protocols therefore sometimes (...) face uncertainty in their decision-making. We examine how a pool of Swiss REC members deal with a number of cases involving human tissue, in order to determine the standards they adhere to, and their understanding and implementation of existing laws and guidelines. There is considerable divergence in the approaches and decisions of Swiss REC members regarding human tissue sample requests, particularly concerning the issue of informed consent. Despite recent trends towards less strict consent requirements for biosample research, many of our respondents continue to employ demanding standards for researchers. The question of informed consent, and the circumstances in which it is required, continues to result in differences of opinion. While room for local and cultural interpretation is essential to the workings of an REC, misunderstanding of existing guidelines, or an absence of regulation in sensitive areas, will only lead to suboptimal functioning of the REC itself. Our data suggests that there is uncertainty and disagreement on the question of consent for human tissue sample, which existing laws and guidelines may not fully clarify. Methods to address these uncertainties should be implemented in order to ensure efficient and harmonious review of research protocols. (shrink)

Este artigo tem por objetivo apresentar o desenvolvimento do conceito de “vontade” na obra O mundo como vontade e representação (1818-9) do filósofo alemão Arthur Schopenhauer. Pretende-se apresentar o conceito perpassando inicialmente pela dicotomia kantiana da Crítica da razão pura entre “coisa em si” e “fenômeno”. Depois, seguiremos as observações feitas por Schopenhauer a essa categorização da realidade e suas ressalvas, para, então, explicitarmos a sua respectiva filosofia fundamentada na oposição entre “vontade” e “representação”. Por último, a influência desse pensamento (...) na denominada “segunda tópica” (pós 1920) na obra do pai da Psicanálise, Sigmund Freud. (shrink)

A realidade virtual tem se tornado cada vez mais presente, o que dá origem a novas questões filosóficas: qual a natureza de experiências em realidade virtual? Seriam elas exatamente como percepções usuais, ou elas possuem algum traço que as diferencia? Seriam ilusórias? Nós argumentamos que experiências em realidade virtual não devem ser tratadas como ilusórias, assim como defendido pela maioria dos teóricos contemporâneos, mas sim como alusórias, condicionadas à incorporação do hardware e ao conhecimento prático envolvido no uso da tecnologia. (...) Para tal, abordamos sua associação com ilusões, exploramos como se relacionam com as nossas experiências do cotidiano e apresentamos nossa proposta de que podem ser compreendidas como alusórias. Em seguida mostramos que seu caráter alusório não as torna indistinguíveis de experiências não-virtuais, uma vez que os limites biológicos e sensório-motores da cognição fornecem o limiar de diferenciação, mesmo nos casos de realidade aumentada. Além disso, exploramos o surgimento da tecnologia de realidade aumentada e discutimos a possibilidade de substituir sistematicamente a percepção por projeções ilusórias. No entanto, até o momento, não há evidências empíricas que sustentem essa possibilidade. Destacamos a importância da relação entre percepção e ação no ambiente físico e argumentamos que erros pontuais em experiências virtuais não caracterizam seu estado como ilusório. (shrink)

Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe (...) that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P‐centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals. (shrink)

This paper discusses the role of attention in the phenomenological analysis of intentional experience in light of the problem of the relation between consciousness, intentionality, and transcendental subjectivity. Are these concepts equivalent? Or should we rather say that there is more to intentionality (and subjectivity) than consciousness? Does subjectivity embrace an unconscious domain? And, if so, how does this unconscious, yet intentional, life of subjectivity operate and how is it related to consciousness? In order to answer these questions, the paper (...) tracks the development of Husserl’s conception of attention from the Logical Investigations to genetic phenomenology, by focusing on his analyses of temporality in the Bernau Manuscripts, on the relation between activity and passivity in the Analyses Concerning Active and Passive Synthesis, and on the issue of the self-constitution of subjectivity. (shrink)

This paper has two main objectives. The first one is to reflect on the validity of data in analysis and projections that underpin the engineering asset management of organizations, considering, on the one hand, a certain resistance or even inadequate use of data and information of a subjective nature and; on the other hand, a consolidated reliance on quantitative approaches and decisions based on data series. The second objective is to contextualize the applicability of combining qualitative data based on experts’ (...) experience and on the tacit knowledge built in organizations, with approaches based essentially on quantitative data, according to the data availability and the decision scenario over the asset life cycle. We present two application of an approach combining quali and quanti data. One example interrelates Statistics with Psychology and the other combines elicitated data about asset indicators with parameters deterministically calculated. Both applications aiming at providing more realistic indicators and supporting the Asset Management process to make more assertive decisions. (shrink)

The status of wild capture fisheries has induced many fisheries and conservation scientists to express concerns about the concept of using forage fish after reduction to fishmeal and fish oil, as feed for farmed animals, particularly in aquaculture. However, a very large quantity of forage fish is being also used untransformed (fresh or frozen) globally for other purposes, such as the pet food industry. So far, no attempts have been made to estimate this quantum, and have been omitted in previous (...) fishmeal and fish oil exploitation surveys. On the basis of recently released data on the Australian importation of fresh or frozen fish for the canned cat food industry, here we show that the estimated amount of raw fishery products directly utilized by the cat food industry equates to 2.48 million metric tonnes per year. This estimate, plus the previously reported global fishmeal consumption for the production of dry pet food suggest that 13.5% of the total 39.0 million tonnes of wild caught forage fish is used for purposes other than human food production. This study attempts to bring forth information on the direct use of fresh or frozen forage fish in the pet food sector that appears to have received little attention to this date and that needs to be considered in the global debate on the ethical nature of current practices on the use of forage fish, a limited biological resource. (shrink)

This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in three sections. The (...) first section provides some background and context. The second motivates our take on this topic and then outlines the central ideas of each paper. The third section highlights the specificity and significance of this approach by considering: a) how this collection departs from existing literature on inter- and trans-disciplinarity, b) what is characteristic about this approach, and c) what role this suggests for the history and philosophy of the life sciences in addressing Grand Challenges. (shrink)

In this paper, the ontological, terminological, epistemological, and ethical aspects of omission are considered in a coherent and balanced framework, based on the idea that there are omissions which are actions and omissions which are non-actions. In particular, we suggest that the approach to causation which best deals with omission is Mackie's INUS conditional proposal. We argue that omissions are determined partly by the ontological conditional structure of reality, and partly by the interests, beliefs, and values of observers. The final (...) upshot is that moral judgments involved in cases of omissions cannot be grounded on, but are the ground for judgments about what INUS conditions count as omissions. (shrink)

Esse artigo visa demonstrar como o psicanalista francês Jacques Lacan delineou e reformulou o conceito freudiano de pulsão de morte no interior dos três registros da experiência humana. Dito isso, iremos inicialmente compreender de forma geral como o conceito de pulsão de morte aparece na obra lacaniana, de maneira a demonstrarmos como ela é reformulada pelo autor francês. Depois, iremos delinear como esse conceito aparece no interior dos registros do Imaginário, Simbólico e Real; desse modo, estaremos envoltos com o Estágio (...) do Espelho desenvolvido por Lacan no decorrer dos anos 1930 e 1940, a teoria do significante fundada por nosso autor mais atentamente nos anos 1950 e por último o registro do Real, o qual foi introduzido com mais atenção a partir dos anos 1960 em diante. (shrink)

The idea of personalised medicine (PM) has gathered momentum recently, attracting funding and generating hopes as well as scepticism. As PM gives rise to differing interpretations, there have been several attempts to clarify the concept. In an influential paper published in this journal, Schleidgen and colleagues have proposed a precise and narrow definition of PM on the basis of a systematic literature review. Given that their conclusion is at odds with those of other recent attempts to understand PM, we consider (...) whether their systematic review gives them an edge over competing interpretations. We have found some methodological weaknesses and questionable assumptions in Schleidgen and colleagues’ attempt to provide a more specific definition of PM. Our perplexities concern the lack of criteria for assessing the epistemic strength of the definitions that they consider, as well as the logical principles used to extract a more precise definition, the narrowness of the pool from which they have drawn their empirical data, and finally their overlooking the fact that definitions depend on the context of use. We are also worried that their ethical assumption that only patients’ interests are legitimate is too simplistic and drives all other stakeholders’ interests—including those that are justifiable—underground, thus compromising any hope of a transparent and fair negotiation among a plurality of actors and interests. As an alternative to the shortcomings of attempting a semantic disciplining of the concept we propose a pragmatic approach. Rather than considering PM to be a scientific concept in need of precise demarcation, we look at it as an open and negotiable concept used in a variety of contexts including at the level of orienting research goals and policy objectives. We believe that since PM is still more an ideal than an achieved reality, a plurality of visions is to be expected and we need to pay attention to the people, reasons and interests behind these alternative conceptions. In other words, the logic and politics of PM cannot be disentangled and disagreements need to be tackled addressing the normative and strategic conflicts behind them. (shrink)

This anthology aims to explore the current Norwegian context of implementation of Responsible Research and Innovation (RRI) and Corporate Social Responsibility (CSR),as well as the challenges and fragilities associated with it. It is grounded in the experience of a networking and learning centre called AFINO (acronym for‘ Ansvarlig Forskning og Innovasjon i NOrge’, or Responsible Research and Innovation in Norway),to which most of the authors of this book are affiliated. Whether the authors are trying to illustrate a fragility or challenge, (...) to understand its origins, or to illustrate how they have been tackled or how things developed in unexpected ways that raise new fragilities and questions, we believe that all chapters contribute to bringing to light the richness of the domains of research, innovation, policy, and business. (shrink)

RRI is a broad concept that is subject to different interpretations. This chapter focuses on the view of RRI as a transformative ideal for reforming the research and innovation system in the service of public interest. This is the normatively strong view of RRI that has attracted many policy-makers and young researchers but left cold many senior researchers and innovators. The transformative vision of RRI has failed to materialise, and RRI remains a marginal reality, even in Norway, where arguably the (...) conditions were more propitious than elsewhere. I attempt to explain the failed transformation, focusing on two key objectives of RRI: the ambition of aligning R&I with societal values and the aspiration to steer R&I through generating a shared responsibility for the future (a prospective joint responsibility in technical terms). Alignment proved very hard to achieve because valuing is steeped in well-established practices, habits, and cognitive-emotional frameworks. These cannot be changed at will. Besides, the ambition to make researchers and innovators more responsive to a wider constituency and additional social responsibilities stumbled against what I call moral saturation, namely the lack of capacity and resources to take on additional moral tasks. Furthermore, modern societies are characterised by a pluralism of values and conceptions of the good life, compounded by the lack of methods for composing value conflicts. These problems come back when we look at what it takes to create expanded shared responsibilities: joint intentions and joint commitments. A formal analysis of how these can be generated shows that they need pre-conditions that are seldom obtaining in the real world of R&I. So, the transformative ambition went against the inertia and entrenched habits of the R&I ecosystem and yet very often the task of promoting the change was given to junior researchers: the most vulnerable and less powerful actors. I conclude that RRI ambition to transform the R&I system is unrealistic. What can be attempted is to develop small-scale experiments outside the mainstream, where institutional barriers and perverse incentives are partially removed or corrected. (shrink)

Michelle Bella & Giovanni Maddalena – Many Peirce scholars wonder about what is going on with the publication of the Writings? André De Tienne – The answer is at once, almost nothing, but a lot! We are in a state of quasi-limbo, and so people do notice that we have not been publishing any volume for the last 10 years and the universal question is, what is happening to the Peirce Edition Project? It is a question that I keep (...) asking myself! But I am glad to share this more publicly, so that peo... (shrink)

How can the discoveries made in the biological sciences play a role in a discussion on the foundation of ethics? This book responds to this question by examining how evolutionism can explain and justify the existence of ethical normativity and the emergence of particular moral systems. Written by a team of philosophers and scientists, the essays collected in this volume deal with the limits of evolutionary explanations, the justifications of ethics, and methodological issues concerning evolutionary accounts of ethics, among other (...) topics. They offer deep insights into the origin and purpose of human moral capacities and of moral systems. (shrink)

The need to better balance the promotion of scientific and technological innovation with risk management for consumer protection has inspired several recent reforms attempting to make regulations more flexible and adaptive. The pharmaceutical sector has a long, established regulatory tradition, as well as a long history of controversies around how to balance incentives for needed therapeutic innovations and protecting patient safety. The emergence of disruptive biotechnologies has provided the occasion for regulatory innovation in this sector. This article investigates the regulation (...) of advanced biotherapeutics in the European Union and shows that it presents several defining features of an adaptive regulation regime, notably institutionalized processes of planned adaptation that allow regulators to gather, generate, and mobilize new scientific and risk evidence about innovative products. However, our in-depth case analysis highlights that more attention needs to be paid to the consequences of the introduction of adaptive regulations, especially for critical stakeholders involved in this new regulatory ecosystem, the capacity and resource requirements placed on them to adapt, and the new tradeoffs they face. In addition, our analysis highlights a deficit in how we currently evaluate the performance and public value proposition of adaptive regulations vis-à-vis their stated goals and objectives. (shrink)

Esse artigo visa apresentar como foi forjado o conceito de pulsão de morte pelo pai da Psicanálise, Sigmund Freud. Nesse sentido, estaremos envoltos com as respectivas modificações do conceito inicial de pulsão principalmente no decorrer no período da Primeira Guerra Mundial até o final da década em questão. Esse momento é chave na teoria da pulsão almejada por Freud nos anos de 1914 até a dualismo pulsional - de pulsões de vida e pulsões de morte - em 1920 com a (...) publicação de Além do Princípio do Prazer, e é esse período que pretendemos desenvolver no presente artigo que antecede o início da Segunda Tópica. (shrink)

Both a significant body of literature and the case study presented here show that digital knowledge repositories struggle to attract the needed level of data and knowledge contribution that they need to be successful. This happens also to high profile and prestigious initiatives. The paper argues that the reluctance of researchers to contribute can only be understood in light of the highly competitive context in which research careers need to be built nowadays and how this affects researchers’ quality of life. (...) Competition and managerialism limit the discretion of researchers in sharing their results and in donating their working time. A growing corpus of research shows that academic researchers are increasingly overworked and highly stressed. This corroborates the point that the room for undertaking additional tasks with future and uncertain benefits is very limited. The paper thus recommends that promoters of digital knowledge repositories focus on the needs of the researchers who are expected to contribute their knowledge. In order to treat them fairly and to ensure the success of the repositories, knowledge sharing needs to be rewarded so as to improve the working conditions of contributors. In order to help implementing this researcher-centred approach, the paper proposes the idea of expediential trust: rewards for contributing should be such that rational, self-interested researchers would freely decide to contribute their knowledge and effort trusting that this would make them better off. (shrink)

The paper points out three serious problems in Ruud ter Meulen’s view of solidarity and of its role in healthcare ethics. First, it is not clear whether and to what extent ter Meulen expects normative concepts to be rooted in existing social practices: his criticism of liberal theories of justice seems to imply a different view on this issue than his implicit assumption that normative concepts are independent from social and historical trends. Second, it is not clear at which level (...) his notion of solidarity is meant to be applied: does it provide principles for individuals or for institutions? Nor is it clear at what level of generality it should work: is it meant for healthcare institutions or for states, for citizens or for healthcare practitioners? Third, it is not at all clear how the communitarian and the universalist aspirations in his conception of solidarity can be reconciled. In light of such difficulties it is argued that within philosophical discourse solidarity can be a useful notion only if it can be clearly distinguished from existing and commonly used ethical concepts. Three examples of such narrow and specific uses of solidarity are presented. Finally, a sceptical view of confining the work of applied philosophers to articulating normative concepts is put forward and an alternative view of blending empirical and philosophical analysis is proposed. This vision of field philosophy requires serious attention and careful understanding of the circumstances and constraints within which normative recommendations operate. It is suggested that such a modest and empirically grounded understanding of normative work is a better way of honouring the belief that philosophy is rooted in social institutions and in complex webs of relations. (shrink)

O presente artigo coloca em evidência uma proposta sobre educação e os respectivos pressupostos para que ela aconteça no sujeito, tendo como referência a pedagogia da hospitalidade com base na filosofia da alteridade em Levinas. Nesse caso, a educação não é vista a partir do movimento do Eu em direção do Outro, mas sim, o contrário. Precisamente o Outro assume o protagonismo pedagógico já que o Eu se abre à possibilidade de acolhida do Outro sem nenhum critério preestabelecido, de forma (...) assimétrica. A partir disso, o texto apresenta a possibilidade de uma hospitalidade a partir da alteridade, tendo o Outro como base de uma relação ética em que o Eu é convidado a participar do convívio do Outro. Essa pedagogia rompe as barreiras de uma educação centrada tão-somente na capacidade do eu egoísta, mas se abre ao infinito das possibilidades da relação onde o Outro se revela com sua história, cultura, e o Eu se adequa às necessidades daquilo que se apresenta como diferente. O rosto do Outro revela ao sujeito o infinito e o valor dele como superação do próprio preconceito por meio da pedagogia da hospitalidade. (shrink)